Temperature Modulation Reveals Three Distinct Stages of Wallerian Degeneration
نویسندگان
چکیده
منابع مشابه
Temperature modulation reveals three distinct stages of Wallerian degeneration.
After peripheral nerve transection, axons distal to the cut site rapidly degenerate, a process termed Wallerian degeneration. In wild-type mice the compound action potential (CAP) disappears by 3 d. Previous studies have demonstrated that cold temperatures and lower extracellular calcium ion (Ca2+) concentrations can slow the rate of Wallerian degeneration. We have incubated isolated sciatic ne...
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Wallerian degeneration was produced in guinea pig sciatic nerves by a crush injury. At intervals of 2, 12, 24, 36, 48, 72, and 96 hours after the crush, the nerves were fixed in osmium tetroxide, and blocks from the distal, degenerating segment identified topographically prior to embedding in Araldite or Epon. Phase and electron microscopic study of serial cross- and longitudinal sections revea...
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Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involveme...
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Two cases of pontine infarct with Wallerian degeneration (WD) of the pontocerebellar fibers are described. WD of pontocerebellar fibers, seen bilaterally along the transverse pontine fibers, is more visible in the middle cerebellar peduncles and extends into the white matter of the cerebellar hemispheres. Understanding the anatomy of the white matter and the temporal evolution of this degenerat...
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(1000mgat days0 and 14). She continued to experienceworseninglowerextremityweakness.Eventually,shereceived6plasmapheresis treatments withminimal improvement. During the entire periodof follow-up at our center, she required 20 to 30mg daily of oral prednisone. Neurological examination prior to the onset of HiCy therapy revealed symmetrically reduced arm abduction (4−/5) and hip flexion strength ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1999
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.19-12-04718.1999